Do I Need a Special Diet During Immunotherapy?

Dr. Sudha Sinha·Medical Oncologist & Hematologist·5 min read
Dr. Sudha Sinha · Senior Consultant & Clinical Director, Medical Oncology, Yashoda Hospitals Somajiguda. Last reviewed: July 2026.
Key Takeaways
  • ✓There's no special diet required during immunotherapy — most people can continue eating a normal, balanced diet.
  • ✓What matters more is eating enough to maintain your strength, and staying well hydrated.
  • ✓Gut symptoms — nausea, diarrhoea, appetite loss — are less common with immunotherapy than with chemotherapy. Don't assume they're routine.
  • ✓Early research suggests a high-fibre, plant-forward diet may support treatment response, but the evidence is still too limited to recommend a specific "immunotherapy diet."
  • ✓Avoid over-the-counter probiotic supplement capsules unless your oncologist has specifically prescribed one.

What Should I Eat During Immunotherapy?

There's no special immunotherapy diet backed by evidence. The same principles that apply to eating well during any cancer treatment apply here too: adequate protein, adequate calories, food safety, staying hydrated.

Can Diet Improve How Immunotherapy Works? (Research Update)

  • ✓Early research suggests that a high-fibre, plant-forward diet may support a healthier gut microbiome and could improve responses to immunotherapy.
  • ✓So far, this evidence comes mainly from studies in melanoma patients and is still too early to recommend a specific "immunotherapy diet."
  • ✓For now, there is no proven diet that makes immunotherapy work better.
  • ✓If you enjoy eating this way, including more vegetables, fruits, whole grains, and legumes as part of a balanced diet is a sensible choice.

A Caution on Probiotic Supplements

  • ✓💊Research on gut bacteria and immunotherapy has found that patients taking over-the-counter probiotic supplements had a weaker response than those who didn't.
  • ✓💊Unless your oncologist has specifically prescribed one, avoid probiotic supplement capsules during treatment.
️ Supplements vs. Food — Not the Same Thing

This caution is about supplement capsules, not food. Curd, buttermilk, and other fermented foods are a different matter and remain a good protein source.

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